Respiratory Nursing

NCLEX Respiratory Nursing: High-Yield Review

By a Resident Physician  ·  Updated 2025  ·  10–12 min read

Respiratory questions appear throughout the NCLEX and require you to recognize deterioration early, know oxygen delivery systems, interpret ABGs, and intervene in the correct sequence.

Respiratory Assessment: What Matters Most

Priority respiratory assessment data

COPD Nursing: The Oxygen Controversy

COPD patients with chronic CO2 retention (hypercapnic) rely on hypoxic drive to breathe. High-flow oxygen can suppress this drive and cause respiratory depression. This is the most tested COPD nursing concept on the NCLEX.

NCLEX rule for COPD oxygen delivery:

Asthma: Acute Exacerbation Management

Mild-moderate exacerbation

  1. Position patient upright (high Fowler's)
  2. Oxygen titrated to SpO2 >92%
  3. Short-acting beta-2 agonist (albuterol) via MDI or nebulizer — priority bronchodilator
  4. Systemic corticosteroids if not rapidly improving
  5. Ipratropium bromide (anticholinergic) may be added for severe exacerbation

Status asthmaticus (life-threatening)

Severe asthma unresponsive to bronchodilators. Signs: inability to speak in full sentences, SpO2 <90% on O2, RR >30, "silent chest" (no wheezing = no air movement — most ominous sign). Action: immediate escalation, IV magnesium sulfate, possible intubation.

Teaching for MDI use: Shake, exhale completely, hold device 1–2 inches from mouth OR use spacer, inhale slowly over 3–5 seconds, hold breath 10 seconds, wait 1 minute between puffs. Rinse mouth after corticosteroid inhaler (prevents oral candidiasis).

Pneumonia: Nursing Assessment and Care

TypeCommon organismsNursing priority
Community-acquiredStrep pneumoniae (#1), Mycoplasma, LegionellaRespiratory isolation if TB suspected; deep breathing and coughing exercises; incentive spirometry
Hospital-acquired (HAP)Gram-negatives (Pseudomonas, Klebsiella), MRSAStrict hand hygiene; head of bed elevation (HOB 30–45°) to prevent VAP
AspirationAnaerobes, gram-negativesAspiration precautions: HOB >30°, check NG tube position, assess gag reflex

Oxygen Delivery Systems: Choosing the Right Device

DeviceFiO2 rangeUse when
Nasal cannula24–44% (1–6 L/min)Mild hypoxia, patient comfort, chronic use
Simple face mask35–55% (6–10 L/min)Moderate hypoxia; minimum 6 L/min to prevent CO2 rebreathing
Non-rebreather mask60–80% (10–15 L/min)Severe hypoxia — keep reservoir bag inflated at all times; first-line for CO poisoning
Venturi maskPrecise 24–50%COPD — most controlled delivery; preferred when exact FiO2 matters
BiPAP/CPAPVariable with PEEPRespiratory failure, sleep apnea, acute decompensated HF (pulmonary edema)

Chest Tubes: Priority Nursing Care

Used for pneumothorax, hemothorax, pleural effusion. Key nursing responsibilities:

NCLEX respiratory order of priority: Any patient with SpO2 below 90% or acute respiratory distress is your first priority — above all other patients regardless of what else is happening. Within respiratory interventions, positioning upright comes first (it's immediate and requires no order), then oxygen, then medication, then notify the provider. Never call the provider before you've done what you can do independently.

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Written by a Resident Physician
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