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Rule Out / Past cases / Bacterial meningitis

Rule Out case #6 · Moderate

Bacterial meningitis: a six-clue practice case

Read the clues in order and name the diagnosis as early as you can. Clues move from the patient’s story to the classic findings.

Play it as a game firstGuess before each clue unlocks, then share your score.

The clues

  1. Clue 1: A 19-year-old who lives in a college dorm has a severe headache.

  2. Clue 2: It came on over the past day, along with a high fever.

  3. Clue 3: Bright light hurts their eyes, and their neck is too stiff to touch chin to chest.

  4. Clue 4: They are becoming confused.

  5. Clue 5: A purple rash that does not fade when pressed appears on their legs.

  6. Clue 6: Spinal fluid is cloudy, with many neutrophils, low glucose and high protein.

Show the diagnosis and takeaways
Diagnosis
Bacterial meningitis
Brain & nervesInfectionSudden onset

What gives it away

  • Fever, neck stiffness and altered mental status are the classic triad, though all three are not always present.
  • A non-blanching purple rash in a young adult suggests meningococcus, which spreads in dorms.
  • Antibiotics must start right away, even before the spinal tap if there will be any delay.
Read the free guideMeningitis: The USMLE Step 1 Guide (CSF & Bugs)

Ran as Rule Out #6 (Friday, October 23, 2026).

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