By R-group: Nonpolar Members: Gly, Ala, Val, Leu, Ile, Pro, Met, Phe, Trp By R-group: Polar uncharged Members: Ser, Thr, Cys, Tyr, Asn, Gln By R-group: Acidic (−) Members: Asp, Glu By R-group: Basic (+) Members: Lys, Arg, His By R-group: Aromatic Members: Phe, Tyr, Trp (UV 280 nm) By R-group: Special Members: Gly (achiral, flexible), Pro (kink), Cys (disulfide) Biochemistry — Amino Acids & Proteins: Primary Defined by: aa sequence (peptide bonds) Biochemistry — Amino Acids & Proteins: Secondary Defined by: α-helix, β-sheet (backbone H-bonds) Biochemistry — Amino Acids & Proteins: Tertiary Defined by: 3-D fold (R-group interactions, disulfides) Biochemistry — Amino Acids & Proteins: Quaternary Defined by: multiple subunits Inhibition: Competitive V_max: —; K_m: ↑ Inhibition: Noncompetitive V_max: ↓; K_m: — Inhibition: Uncompetitive V_max: ↓; K_m: ↓ Inhibition: Mixed V_max: ↓; K_m: ↑/↓ Aerobic yields per glucose: Glycolysis Location: cytosol; Yield: 2 ATP, 2 NADH, 2 pyruvate Aerobic yields per glucose: Pyruvate → acetyl-CoA Location: mito matrix; Yield: 2 NADH (×2 pyr) Aerobic yields per glucose: TCA (×2 turns) Location: matrix; Yield: 6 NADH, 2 FADH₂, 2 GTP Aerobic yields per glucose: ETC / Ox-phos Location: inner membrane; Yield: NADH≈2.5, FADH₂≈1.5 ATP Aerobic yields per glucose: Total Yield: ≈30–32 ATP Molecular Biology & Genetics: Silent Effect: same aa (degeneracy) Molecular Biology & Genetics: Missense Effect: different aa Molecular Biology & Genetics: Nonsense Effect: premature stop Molecular Biology & Genetics: Frameshift Effect: insertion/deletion (not ×3) Cell Biology & Physiology: Simple/facilitated diffusion Energy: none (down gradient) Cell Biology & Physiology: Primary active (Na⁺/K⁺ ATPase) Energy: ATP Cell Biology & Physiology: Secondary active Energy: ion gradient Cell Biology & Physiology: Osmosis (water) Energy: none Biochemistry — Amino Acids & Proteins: pI pH of net-zero charge. Below pI → protonated (+); above pI → (−). Biochemistry — Amino Acids & Proteins: Hemoglobin (cooperative, 4 subunits) vs myoglobin (hyperbolic, 1 subunit, higher affinity). Biochemistry — Amino Acids & Proteins: Right shift ↓ O₂ affinity, unloads to tissue: ↑CO₂, ↓pH (Bohr effect), ↑temperature, ↑2,3-BPG. Biochemistry — Amino Acids & Proteins: Carbs mono/di/polysaccharides; glycosidic bonds; glycogen (branched storage), cellulose (β, structural). Biochemistry — Amino Acids & Proteins: Lipids triglycerides (storage), phospholipids (membranes, amphipathic), steroids (cholesterol → hormones), fat-soluble vitamins (ADEK). Biochemistry — Amino Acids & Proteins: Nucleic acids nucleotide = sugar + phosphate + base; A-T(U), G-C; antiparallel. Metabolism & Bioenergetics: Anaerobic pyruvate → lactate (regenerates NAD⁺); only 2 ATP. Metabolism & Bioenergetics: Gluconeogenesis liver; reverses glycolysis at 3 irreversible steps. Metabolism & Bioenergetics: β-oxidation fatty acids → acetyl-CoA (lots of ATP); occurs in mito. Metabolism & Bioenergetics: Ketogenesis fasting/low-carb, from acetyl-CoA (liver). Metabolism & Bioenergetics: PPP makes NADPH + ribose-5-P (biosynthesis, not ATP). Metabolism & Bioenergetics: ATP synthase (complex V) uses H⁺ flow to make ATP. O₂ = final e⁻ acceptor → H₂O. Molecular Biology & Genetics: Replication (S phase): semiconservative; helicase, primase, DNA pol (5′→3′), leading vs lagging (Okazaki), ligase, telomerase. Molecular Biology & Genetics: Transcription (nucleus): RNA pol II; pre-mRNA → 5′ cap, poly-A tail, splicing (introns out, exons kept). Molecular Biology & Genetics: Translation (ribosome): initiation (AUG=Met), elongation, termination (stop codons UAA/UAG/UGA); tRNA anticodons. Molecular Biology & Genetics: PCR amplify DNA (denature, anneal, extend). Gel = separate by size (− → +). Cell Biology & Physiology: Nucleus (DNA), mitochondria (ATP, own DNA), rough ER (protein synth), smooth ER (lipids, detox), Golgi (modify/ship), lysosome (digest), peroxisome (β-oxidation, H₂O₂). Cell Biology & Physiology: Meiosis 2 divisions → 4 haploid gametes; crossing over (prophase I) → diversity. Cell Biology & Physiology: Circulatory heart → arteries → capillaries → veins; left heart systemic, right pulmonary. Cell Biology & Physiology: Respiratory gas exchange at alveoli; O₂/CO₂ diffusion. Cell Biology & Physiology: Renal nephron — filter (glomerulus), reabsorb, secrete; regulates volume, pH, electrolytes. Cell Biology & Physiology: Digestive mechanical + enzymatic; absorption in small intestine. Cell Biology & Physiology: Immune innate (fast, nonspecific) + adaptive (B cells/antibodies, T cells). Physical constants: g (gravity) Value: 9.8 m/s² (≈10) Physical constants: G (gravitation) Value: 6.67×10⁻¹¹ N·m²/kg² Physical constants: k (Coulomb) Value: 8.99×10⁹ N·m²/C² (≈9×10⁹) Physical constants: c (light) Value: 3.0×10⁸ m/s Physical constants: h (Planck) Value: 6.63×10⁻³⁴ J·s Physical constants: N_A (Avogadro) Value: 6.022×10²³ /mol Physical constants: R (gas) Value: 8.314 J/mol·K = 0.0821 L·atm/mol·K Physical constants: e (charge) Value: 1.6×10⁻¹⁹ C Physical constants: ε₀ (permittivity) Value: 8.85×10⁻¹² C²/N·m² Physical constants: Symbol: K_w Value: 1.0×10⁻¹⁴ (25 °C) Conversions: 1 atm Equivalent: 760 mmHg = 760 torr = 101 kPa Conversions: Quantity: STP Equivalent: 0 °C, 1 atm → 22.4 L/mol (ideal) Conversions: Temperature Equivalent: K = °C + 273 Conversions: 1 cal Equivalent: 4.18 J Conversions: 1 mole gas (STP) Equivalent: 22.4 L Conversions: 1 eV Equivalent: 1.6×10⁻¹⁹ J Physics — Complete Equation Sheet: Elastic p: ✔; KE: ✔ conserved Physics — Complete Equation Sheet: Inelastic p: ✔; KE: ✖ (lost) Physics — Complete Equation Sheet: Perfectly inelastic p: ✔; KE: ✖ (stick together) Standing-wave harmonics: String / open pipe f_n: n·v/2L; n: 1,2,3… Standing-wave harmonics: Closed pipe (1 end) f_n: n·v/4L; n: odd only Physics — Complete Equation Sheet: Series Resistors: R_eq=ΣR (same I); Capacitors: 1/C_eq=Σ1/C Physics — Complete Equation Sheet: Parallel Resistors: 1/R_eq=Σ1/R (same V); Capacitors: C_eq=ΣC General Chemistry: Atomic radius Across → (L→R): ↓; Down ↓: ↑ General Chemistry: Ionization energy Across → (L→R): ↑; Down ↓: ↓ General Chemistry: Electronegativity Across → (L→R): ↑; Down ↓: ↓ General Chemistry: Electron affinity Across → (L→R): ↑ (more −); Down ↓: ↓ General Chemistry: e⁻ domains: 2 Shape (0 LP): linear; Angle: 180° General Chemistry: e⁻ domains: 3 Shape (0 LP): trigonal planar; Angle: 120° General Chemistry: e⁻ domains: 4 Shape (0 LP): tetrahedral; Angle: 109.5° General Chemistry: e⁻ domains: 5 Shape (0 LP): trig. bipyramidal; Angle: 90/120° General Chemistry: e⁻ domains: 6 Shape (0 LP): octahedral; Angle: 90° General Chemistry: ΔH: − ΔS: +; Spontaneity: always (ΔG<0) General Chemistry: ΔH: + ΔS: −; Spontaneity: never General Chemistry: ΔH: − ΔS: −; Spontaneity: low T General Chemistry: ΔH: + ΔS: +; Spontaneity: high T Naming priority: high → low: Carboxylic acid Structure: –COOH Naming priority: high → low: Ester Structure: –COOR Naming priority: high → low: Amide Structure: –CONH₂ Naming priority: high → low: Aldehyde Structure: –CHO (terminal) Naming priority: high → low: Ketone Structure: C=O (internal) Naming priority: high → low: Alcohol Structure: –OH Naming priority: high → low: Amine Structure: –NH₂ Organic Chemistry: Steps SN1: 2 (carbocation); SN2: 1 (concerted) Organic Chemistry: Rate law SN1: [substrate]; SN2: [substrate][Nu] Organic Chemistry: Best substrate SN1: 3° > 2°; SN2: 1° > 2° Organic Chemistry: Stereochem SN1: racemization; SN2: inversion Organic Chemistry: Favored by SN1: polar protic, weak Nu; SN2: polar aprotic, strong Nu General Chemistry: Arrhenius k = A·e^(−Ea/RT) ↑T or catalyst (↓Ea) → ↑k. General Chemistry: Q vs K QK → reverse; Q=K → at eq. General Chemistry: Le Châtelier stress (add reactant, ↑P by ↓volume toward fewer gas moles, ΔT) shifts to relieve it. Adding an inert gas at constant volume does not shift equilibrium. General Chemistry: AN OX / RED CAT oxidation at anode, reduction at cathode (both cells). General Chemistry: IR O–H broad ~3300, C=O sharp ~1700, N–H ~3300. General Chemistry: ¹H NMR shift=environment, splitting=n+1 neighbors, integration=# H. General Chemistry: UV-Vis conjugation; Beer's law A = εbc (absorbance ∝ concentration). Mass spec: m/z, molecular ion. Organic Chemistry: Structural (constitutional): different connectivity. Organic Chemistry: Stereoisomers same connectivity, different 3-D arrangement. Organic Chemistry: Enantiomers nonsuperimposable mirror images (opposite at every stereocenter); identical physical properties except they rotate plane-polarized light oppositely and behave differently in chiral environments. Organic Chemistry: Diastereomers differ at some but not all stereocenters; different physical properties (includes cis/trans). Organic Chemistry: Meso has stereocenters but an internal mirror plane → achiral overall. Organic Chemistry: Nucleophilic addition (aldehydes/ketones): + alcohol → hemiacetal/acetal; + amine → imine (Schiff base). Organic Chemistry: Nucleophilic acyl substitution (acid derivatives): reactivity acyl chloride > anhydride > ester > amide. Classical vs operant: Who Classical: Pavlov; Operant: Skinner Classical vs operant: Learns Classical: stimulus–stimulus; Operant: behavior–consequence Classical vs operant: Response Classical: involuntary; Operant: voluntary PSY-2 Learning, Motivation & Personality: Increase behavior Add (+): + reinforce; Remove (−): − reinforce PSY-2 Learning, Motivation & Personality: Decrease behavior Add (+): + punish; Remove (−): − punish Biological Basis of Behavior: Frontal lobe Role: planning, personality, motor Biological Basis of Behavior: Parietal Role: somatosensation Biological Basis of Behavior: Temporal Role: hearing, language Biological Basis of Behavior: Occipital Role: vision Biological Basis of Behavior: Amygdala Role: fear/emotion Biological Basis of Behavior: Hippocampus Role: memory formation Biological Basis of Behavior: Hypothalamus Role: homeostasis, endocrine Biological Basis of Behavior: Cerebellum Role: coordination/balance Sociology & Social Psychology: Functionalism Core idea: society = interdependent parts (Durkheim) Sociology & Social Psychology: Conflict Core idea: competition over resources/power (Marx) Sociology & Social Psychology: Symbolic interactionism Core idea: meaning from interaction (Mead) Sociology & Social Psychology: Social constructionism Core idea: reality is socially built PSY-1 Sensation, Perception & Cognition: Sensation transduction of stimulus to neural signal. PSY-1 Sensation, Perception & Cognition: Perception brain's organization/interpretation. PSY-1 Sensation, Perception & Cognition: Absolute threshold min. detectable 50% of the time. JND / Weber's law: difference is a constant ratio. PSY-1 Sensation, Perception & Cognition: Bottom-up (data-driven) vs top-down (expectation-driven). PSY-1 Sensation, Perception & Cognition: Piaget sensorimotor → preoperational → concrete → formal operational. Assimilation (fit to schema) vs accommodation (change schema). PSY-2 Learning, Motivation & Personality: Psychoanalytic (Freud): id/ego/superego; ego defense mechanisms — repression, denial, projection, displacement, rationalization, reaction formation, regression, sublimation. PSY-2 Learning, Motivation & Personality: Humanistic (Rogers, Maslow): self-actualization, unconditional positive regard. PSY-2 Learning, Motivation & Personality: Trait Big Five (OCEAN). PSY-2 Learning, Motivation & Personality: Social-cognitive (Bandura): reciprocal determinism, self-efficacy, locus of control. PSY-2 Learning, Motivation & Personality: Erikson (psychosocial, 8 stages: trust vs mistrust … integrity vs despair). PSY-2 Learning, Motivation & Personality: Kohlberg (moral: preconventional → conventional → postconventional). PSY-2 Learning, Motivation & Personality: Vygotsky (zone of proximal development, scaffolding). Sociology & Social Psychology: Attribution dispositional vs situational; fundamental attribution error; self-serving bias. Sociology & Social Psychology: Conformity (Asch), obedience (Milgram), groupthink, group polarization, bystander effect, social facilitation/loafing, deindividuation. Sociology & Social Psychology: Attitudes cognitive dissonance (Festinger); persuasion (central vs peripheral route, ELM). Sociology & Social Psychology: Health disparities access, incidence/prevalence, sick role (Parsons), medicalization, social epidemiology.