How lab values are tested on the NCLEX-RN

Lab items fall mainly under Reduction of Risk Potential (12% of the 2026 test plan) and Pharmacological Therapies. The question is almost always "which result needs follow-up?" or "what should the nurse do first?"

workspace_premium Value + client + action

A potassium of 3.3 mEq/L matters much more in a client taking digoxin. A platelet count of 90,000/mm³ matters much more in a client on heparin. Read every lab in the context of the client's drugs and condition, then choose the action.

CompareRange,baseline,trendAssessSigns thatmatch thevalueLinkDrugs anddiagnosisActHold, treat,notifyReportCriticalvalue perpolicy
Abnormal lab workflow. A critical value is reported to the provider promptly, and the report is documented, per facility policy.

Electrolytes

Electrolyte imbalances produce predictable neuromuscular and cardiac signs.

ElectrolyteUsual adult rangeLow: key signsHigh: key signs
Sodium135–145 mEq/LConfusion, headache, seizures; correct slowlyThirst, agitation, dry mucosa; seizures if severe
Potassium3.5–5.0 mEq/LMuscle weakness, cramps, constipation, flat T waves, U wavesMuscle weakness, peaked T waves, dysrhythmias
Calcium (total)About 8.5–10.5 mg/dLTetany, Trousseau and Chvostek signs, prolonged QTWeakness, constipation, kidney stones, confusion
MagnesiumAbout 1.5–2.5 mg/dLTremor, hyperreflexia, torsades; makes hypokalemia hard to correctLoss of deep tendon reflexes, respiratory depression, hypotension
PhosphorusAbout 2.5–4.5 mg/dLWeakness (refeeding syndrome)Usually with kidney failure; itching, low calcium

Ranges vary by laboratory and units; use the reference range on the client's report.

Hypokalemia (< 3.5)Causes: diuretics, vomiting, NG suctionWeakness, leg cramps, constipationFlat T waves, U waves↑ Digoxin toxicity riskReplace K⁺ as ordered; check urineoutput firstHyperkalemia (> 5.0)Causes: kidney failure, ACE inhibitors,K⁺-sparing diureticsWeakness, paresthesiasPeaked T waves, wide QRSRisk of VF and asystoleCardiac monitor; anticipate calcium,insulin and glucosevs
Potassium safety. IV potassium is always diluted and given on a pump, never as an IV push; peripheral rates are limited by policy.

Blood counts and coagulation

Counts and clotting tests guide infection precautions, bleeding precautions, and anticoagulant doses.

TestUsual adult rangeNursing significance
WBCAbout 5,000–10,000/mm³High: infection, inflammation, steroids. Low: infection risk
Absolute neutrophil countBelow 500/mm³ = severe neutropeniaNeutropenic precautions: hand hygiene, avoid sick contacts, report fever immediately
HemoglobinAbout 12–16 g/dL (F), 14–18 g/dL (M)Low: bleeding, anemia; assess for fatigue, tachycardia, dyspnea
HematocritAbout 37–47% (F), 42–52% (M)Rises with dehydration; falls with bleeding or fluid overload
Platelets150,000–400,000/mm³Low: bleeding precautions; a fall of 50% on heparin suggests HIT
PT/INRINR about 1.0 off warfarin; target usually 2–3Monitors warfarin; high INR → hold and notify
aPTTAbout 30–40 secondsMonitors IV heparin (therapeutic about 1.5–2.5 × control)

Bleeding precautions: soft toothbrush, electric razor, no IM injections if avoidable, pressure on puncture sites.

Arterial blood gases

Interpret ABGs in the same order every time.

Steps1. pH< 7.35 acidosis; > 7.45 alkalosis2. PaCO₂Respiratory: 35–45; moves opposite to pH3. HCO₃⁻Metabolic: 22–26; moves with pH4. MatchThe value that matches the pH is the cause5. CompensationOther value moving to correct? pH normal = full
ABG steps. A common memory aid is ROME: Respiratory Opposite, Metabolic Equal (direction of pH vs the causative value).
DisorderpHPrimary changeCommon causes
Respiratory acidosis↓PaCO₂ ↑Hypoventilation: opioids, COPD, neuromuscular weakness
Respiratory alkalosis↑PaCO₂ ↓Hyperventilation: anxiety, pain, early PE, high altitude
Metabolic acidosis↓HCO₃⁻ ↓DKA, lactic acidosis, kidney failure, diarrhea
Metabolic alkalosis↑HCO₃⁻ ↑Vomiting, NG suction, diuretics, excess antacids

Kussmaul respirations are the lungs compensating for metabolic acidosis.

Therapeutic drug levels and other values

Narrow-therapeutic-range drugs are monitored with blood levels.

Drug levelsDigoxinAbout 0.5–2.0 ng/mLLithiumAbout 0.6–1.2 mEq/LPhenytoinAbout 10–20 mcg/mLVancomycinTrough or AUC perprotocol
Drug levels. Lower digoxin targets (about 0.5–0.9 ng/mL) are often used in heart failure. Draw troughs just before the next dose.
TestUsual adult valueNursing note
Fasting glucose70–99 mg/dLBelow 70 = hypoglycemia; treat with the 15-15 rule
HbA1cBelow 5.7%; 6.5% or higher = diabetesReflects about 3 months of glucose
BUNAbout 10–20 mg/dLRises with dehydration, GI bleeding, kidney failure
CreatinineAbout 0.6–1.2 mg/dLBest routine marker of kidney function; check before nephrotoxic drugs and contrast
AlbuminAbout 3.5–5.0 g/dLLow: malnutrition, liver disease, edema, poor wound healing
BNPBelow 100 pg/mLElevated in heart failure

Critical-value thresholds are set by each facility.

NGN-style case

Prioritizing among several abnormal values is a frequent item type.

functions Clinical judgment case — which value first?

The nurse reviews morning labs. Which result requires the most immediate action? (A) Hemoglobin 11.8 g/dL in a client after surgery; (B) potassium 6.4 mEq/L in a client with kidney failure; (C) glucose 182 mg/dL in a client on prednisone; (D) INR 2.6 in a client on warfarin for atrial fibrillation.

  1. Recognize cues: potassium 6.4 mEq/L is well above 5.0.
  2. Analyze: hyperkalemia can cause fatal dysrhythmias.
  3. The other results are mildly abnormal or within the expected target (INR 2.6 is therapeutic).
  4. Act: assess the client, place on a cardiac monitor, and notify the provider; anticipate treatment to stabilize the heart and lower potassium.

Answer. Client B. Hyperkalemia is the greatest immediate threat to life.