What It Is

Ventricular fibrillation is a life-threatening arrhythmia in which the ventricles quiver chaotically instead of contracting in a coordinated way, so the heart pumps no blood. It is one of the main rhythms causing sudden cardiac arrest. Without immediate treatment, the absence of cardiac output leads to loss of consciousness within seconds and death within minutes.

Causes

The most common precipitant is acute myocardial ischemia or infarction, which destabilizes the ventricular myocardium. Other causes include underlying structural heart disease and cardiomyopathies, electrolyte abnormalities (such as potassium and magnesium disturbances), prolonged QT and certain drugs, and channelopathies. Ventricular tachycardia can degenerate into ventricular fibrillation.

Recognition

On the monitor or ECG, ventricular fibrillation appears as a chaotic, irregular, wavering baseline without discernible P waves, QRS complexes, or T waves; it may be coarse or fine. Clinically, the patient is pulseless and unresponsive. Recognizing a pulseless patient with this pattern as a shockable rhythm is the critical first step, and it must be distinguished from artifact and from asystole.

Treatment

Ventricular fibrillation is treated with immediate defibrillation — an unsynchronized electrical shock — which is the only definitive therapy, combined with high-quality CPR to maintain perfusion between shocks. In the ACLS algorithm, CPR and early defibrillation are prioritized, with epinephrine and antiarrhythmics (amiodarone or lidocaine) as adjuncts, while reversible causes are sought and corrected. After successful resuscitation, an implantable defibrillator is often considered.